Description

8-Bromo-7-Methoxy-1,6-Naphthyridin-4(1H)-One is a high-purity, advanced pharmaceutical intermediate belonging to the naphthyridine class of heterocyclic compounds. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and antiviral research. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially kinase inhibitors and other targeted therapies.
• Drug Discovery & Medicinal Chemistry: Serves as a versatile scaffold for constructing compound libraries and exploring structure-activity relationships (SAR) in early-stage R&D.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and the commercial-scale production of active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed as a tool compound in enzymatic assays and biological target validation studies.
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and commercial drug substances under GMP guidelines.

Basic Information

Product Name	8-Bromo-7-Methoxy-1,6-Naphthyridin-4(1H)-One
CAS No.	952138-17-9
Molecular Formula	C9H7BrN2O2
Molecular Weight	255.07 g/mol
Synonyms	8-Bromo-7-methoxy-1,6-naphthyridin-4(1H)-one; 8-Bromo-7-methoxy-1H-1,6-naphthyridin-4-one; 1,6-Naphthyridin-4(1H)-one, 8-bromo-7-methoxy-; 952138-17-9; 8-Br-7-MeO-1,6-naphthyridin-4-one
EINECS	Contact for details

Quality Control

Our 8-Bromo-7-Methoxy-1,6-Naphthyridin-4(1H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide full traceability and detailed Certificates of Analysis (COA) to support your regulatory and R&D requirements. Specifications can be tailored to meet specific project needs, including custom purity grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); keep the container tightly sealed under inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.