Description

3-(3-Chloro-4-Fluorophenyl)-2-Methyl-1-Propene is a high-purity fluorinated and chlorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both halogen substituents on the phenyl ring and a reactive terminal alkene, makes it a versatile intermediate for constructing complex molecules. This compound is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the halogenated aromatic core contributes to biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers with tailored electronic or surface properties.
• Ligand and Catalyst Development: Employed in the preparation of sophisticated phosphine or N-heterocyclic carbene (NHC) ligands for asymmetric catalysis.
• Chemical Biology Probes: Utilized to synthesize tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical raw material for custom synthesis organizations (CSOs) producing bespoke compounds for client R&D programs.

Basic Information

Product Name	3-(3-Chloro-4-Fluorophenyl)-2-Methyl-1-Propene
CAS No.	951888-17-8
Molecular Formula	C10H10ClF
Molecular Weight	184.64 g/mol
Synonyms	1-(3-Chloro-4-fluorophenyl)-2-methylpropene; 2-Methyl-1-(3-chloro-4-fluorophenyl)prop-1-ene; 3-Chloro-4-fluoro-α-methylstyrene; (3-Chloro-4-fluorophenyl)isobutylene; 951888-17-8; 3-(3-Chloro-4-fluorophenyl)-2-methylpropene
EINECS	Contact for details

Quality Control

Our production of 3-(3-Chloro-4-Fluorophenyl)-2-Methyl-1-Propene adheres to strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and oxidizing agents. Due to its sensitivity, minimize exposure to air and moisture during handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.