Description

5-(Trifluoromethyl)Nicotinonitrile is a high-value, fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a nitrile and a trifluoromethyl group on the pyridine ring, makes it indispensable for modulating the physicochemical properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Material Science: Serves as a monomer or functionalizing agent for creating specialty polymers and liquid crystals with specific electronic or optical properties.
• Chemical Synthesis: Versatile building block for constructing complex heterocyclic compounds via reactions involving the nitrile group, such as cycloadditions or reductions.
• Fluorine Chemistry: A valuable source of a CF3-substituted pyridine scaffold for introducing fluorine atoms into molecules to alter their polarity, stability, and binding characteristics.

Basic Information

Product Name	5-(Trifluoromethyl)Nicotinonitrile
CAS No.	951624-83-2
Molecular Formula	C7H3F3N2
Molecular Weight	172.11 g/mol
Synonyms	3-Cyano-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-3-pyridinecarbonitrile; Nicotinonitrile, 5-(trifluoromethyl)-; 3-Pyridinecarbonitrile, 5-(trifluoromethyl)-; 5-Trifluoromethylpyridine-3-carbonitrile; 5-Cyanopyridine-3-trifluoromethyl; Pyridine, 3-cyano-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Nicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.