Description

1-Piperidinecarboxylic Acid, 4-(5-Bromo-2-Thienyl)-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a unique piperidine-thiophene scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, particularly those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probes: Employed in the development of molecular probes to study enzyme function and biological pathways.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.
• Library Synthesis: Valuable for generating focused combinatorial libraries around the piperidine-thiophene pharmacophore for high-throughput screening.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 4-(5-Bromo-2-Thienyl)-, 1,1-Dimethylethyl Ester
CAS No.	951259-22-6
Molecular Formula	C14H20BrNO2S
Molecular Weight	346.28 g/mol
Synonyms	tert-Butyl 4-(5-bromothiophen-2-yl)piperidine-1-carboxylate; 4-(5-Bromo-2-thienyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 4-(5-Bromothiophen-2-yl)piperidine-1-carboxylic acid tert-butyl ester; Boc-4-(5-bromothiophen-2-yl)piperidine; 951259-22-6; 4-(5-Bromo-thiophen-2-yl)-piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of 1-Piperidinecarboxylic Acid, 4-(5-Bromo-2-Thienyl)-, 1,1-Dimethylethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. All material is characterized and released against comprehensive specifications, including identity confirmation by spectroscopic methods and purity assessment by HPLC. Certificates of Analysis (COA) detailing all critical quality attributes are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.