Description

6-Chloro-3-Fluoronicotinaldehyde is a versatile and highly functionalized pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique halogenated and aldehyde-substituted structure makes it an indispensable precursor for constructing complex heterocyclic scaffolds. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Development: The aldehyde and halogen functionalities allow for its use in creating novel chelating ligands and organocatalysts for asymmetric synthesis.
• Material Science Research: Building block for the synthesis of functionalized polymers and organic electronic materials.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl systems.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target identification.

Basic Information

Product Name	6-Chloro-3-Fluoronicotinaldehyde
CAS No.	950691-52-8
Molecular Formula	C6H3ClFNO
Molecular Weight	159.55 g/mol
Synonyms	3-Fluoro-6-chloropyridine-5-carboxaldehyde; 5-Chloro-2-fluoropyridine-3-carboxaldehyde; 6-Chloro-3-fluoropyridine-5-carbaldehyde; 6-Chloro-3-fluoro-5-pyridinecarboxaldehyde; 6-Chloro-3-fluoronicotinaldehyde; 3-Fluoro-6-chloro-5-pyridinecarboxaldehyde; 6-Chloro-3-fluoropyridine-5-carboxaldehyde; 5-Formyl-2-chloro-3-fluoropyridine
EINECS	Contact for details

Quality Control

Our 6-Chloro-3-Fluoronicotinaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.