Description

tert-Butyl 2-(5-Bromopyridin-2-Yl)-2-Oxoethylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a bromopyridine core protected by a Boc (tert-butoxycarbonyl) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used as a versatile building block for structure-activity relationship (SAR) studies and lead optimization.
• Kinase Inhibitor Development: Serves as a core scaffold or substituent in the synthesis of protein kinase inhibitors for oncology and inflammatory diseases.
• Peptidomimetic Synthesis: The Boc-protected amine functionality makes it suitable for constructing peptide-like molecules and protease inhibitors.
• Chemical Biology Probes: Employed in the creation of labeled or tagged molecules for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 2-(5-Bromopyridin-2-Yl)-2-Oxoethylcarbamate
CAS No.	950176-70-2
Molecular Formula	C12H15BrN2O3
Molecular Weight	315.17 g/mol
Synonyms	Boc-2-amino-1-(5-bromo-2-pyridinyl)ethanone; 2-[(tert-Butoxycarbonyl)amino]-1-(5-bromopyridin-2-yl)ethan-1-one; 1-(5-Bromo-2-pyridinyl)-2-[(2-methyl-2-propanyl)oxycarbonyl]amino]ethanone; 2-(Boc-amino)-1-(5-bromo-2-pyridinyl)ethanone; N-Boc-2-amino-1-(5-bromo-2-pyridinyl)ethanone; tert-Butyl N-[2-(5-bromo-2-pyridinyl)-2-oxoethyl]carbamate; 950176-70-2; Boc-AE(5-Br-Py)
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(5-Bromopyridin-2-Yl)-2-Oxoethylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure compliance with research and development specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.