Description

3-Pyridinecarboxamide, n-[1-(Phenylmethyl)-3-Pyrrolidinyl]-6-(Trifluoromethyl)- is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating a trifluoromethyl group. This compound is of significant value in modern medicinal chemistry, where it serves as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of targeted therapeutics, particularly in areas requiring specific molecular scaffolds for receptor binding and metabolic stability.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• API Development: Serves as a core scaffold for constructing complex molecules with potential therapeutic activity.
• Biochemical Tool Compound: May be utilized in vitro to study enzyme inhibition or receptor-ligand interactions in pharmacological research.
• Custom Synthesis Building Block: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.

Basic Information

Product Name	3-Pyridinecarboxamide, n-[1-(Phenylmethyl)-3-Pyrrolidinyl]-6-(Trifluoromethyl)-
CAS No.	950069-16-6
Molecular Formula	C18H18F3N3O
Molecular Weight	349.35 g/mol
Synonyms	N-[1-(Phenylmethyl)-3-pyrrolidinyl]-6-(trifluoromethyl)-3-pyridinecarboxamide; N-[1-Benzyl-3-pyrrolidinyl]-6-(trifluoromethyl)nicotinamide; 6-(Trifluoromethyl)-N-[1-benzyl-3-pyrrolidinyl]pyridine-3-carboxamide; 950069-16-6; UNII-7V8W1K0S3R; 7V8W1K0S3R; BDBM50382889; AKOS025310923; ZINC000003869901
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support development and commercial projects with materials suitable for use under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.