Description

tert-Butyl 2-(6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)acetate is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester group, making it a critical reagent for modern synthetic methodologies. This compound is essential for facilitating key carbon-carbon bond-forming reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester coupling partner for the synthesis of biaryl and heterobiaryl structures, which are common motifs in drug discovery.
• Pharmaceutical Intermediate: A key building block in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, leveraging its ability to introduce complex substituents.
• Material Science Research: Employed in the synthesis of organic electronic materials and ligands for catalysts.
• Process Chemistry & Scale-Up: Provides a reliable and stable boronate source for optimizing and scaling up synthetic routes from laboratory to pilot plant.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting cutting-edge organic synthesis projects.

Basic Information

Product Name	tert-Butyl 2-(6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)acetate
CAS No.	949922-33-2
Molecular Formula	C21H32BNO4
Molecular Weight	373.30 g/mol
Synonyms	2-(6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinolin-2-yl)acetic acid tert-butyl ester; tert-Butyl (6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-1H-isoquinolin-2(6H)-yl)acetate; 1,2,3,4-Tetrahydro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline-2-acetic acid 1,1-dimethylethyl ester; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline-2-acetic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)acetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature: 2-8°C for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.