Description

Pyrrolidine, 2-[Bis(3,5-Dimethylphenyl)[(Trimethylsilyl)Oxy]Methyl]-, (2R)- is a high-purity, chiral organosilicon compound featuring a pyrrolidine scaffold with sterically hindered aryl groups. This advanced synthetic intermediate is critical for its role in facilitating stereoselective transformations, particularly in the synthesis of complex pharmaceutical molecules and fine chemicals. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise control over molecular architecture.

Application

• Pharmaceutical Intermediate: A key chiral building block in the asymmetric synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drug candidates.
• Catalyst Ligand Precursor: Used in the development and preparation of novel chiral ligands for asymmetric catalysis, including hydrogenation and cross-coupling reactions.
• Agrochemical Synthesis: Serves as a sophisticated intermediate in the research and production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science Research: Employed in academic and industrial R&D for creating novel silicon-containing polymers or functional materials with specific stereochemical properties.
• Process Chemistry: Utilized in scale-up and optimization studies for the commercial manufacturing of high-value, optically active compounds.

Basic Information

Product Name	Pyrrolidine, 2-[Bis(3,5-Dimethylphenyl)[(Trimethylsilyl)Oxy]Methyl]-, (2R)-
CAS No.	948594-99-8
Molecular Formula	C24H35NOSi
Molecular Weight	381.63 g/mol
Synonyms	(2R)-2-[[Bis(3,5-dimethylphenyl)(trimethylsilyloxy)methyl]pyrrolidine; (R)-2-((Bis(3,5-dimethylphenyl)((trimethylsilyl)oxy)methyl)pyrrolidine; 2-[[Bis(3,5-dimethylphenyl)(trimethylsilyloxy)methyl]pyrrolidine, (2R)-; Chiral Pyrrolidine Silyl Ether; (R)-TMS-Protected Pyrrolidine Diol Derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of Pyrrolidine, 2-[Bis(3,5-Dimethylphenyl)[(Trimethylsilyl)Oxy]Methyl]-, (2R)- adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and GC-MS. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is light-sensitive and easily oxidized; prolonged exposure to air, light, or moisture should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.