Description

Methyl 2-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Yl)Acetate CAS NO 948594-81-8 is a high-purity, advanced pharmaceutical intermediate featuring a pyrimidine core and a pinacol boronate ester protecting group. This compound is critically important as a key building block in modern medicinal chemistry, enabling efficient cross-coupling reactions like the Suzuki-Miyaura reaction. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, agrochemical, and biotechnology industries for the synthesis of novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, antiviral, and CNS drug discovery programs.
• Suzuki-Miyaura Cross-Coupling Reagent: The boronate ester group enables efficient carbon-carbon bond formation with aryl/heteroaryl halides, a cornerstone reaction in constructing complex drug-like molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require functionalized pyrimidine structures.
• Material Science & OLED Development: Serves as a precursor for creating organic electronic materials, ligands for catalysts, and emissive layers in display technologies.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and bioconjugation reagents for studying biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	Methyl 2-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Yl)Acetate
CAS No.	948594-81-8
Molecular Formula	C15H21BN2O4
Molecular Weight	304.15 g/mol
Synonyms	2-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)acetic acid methyl ester; Methyl (5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)acetate; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2-acetic acid methyl ester; 2-Pyrimidineacetic acid, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; Methyl 2-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl]acetate; 948594-81-8; BRN 15305887
EINECS	Contact for details

Quality Control

Our Methyl 2-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Yl)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliable performance and consistency in your critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.