Description

Fresolimumab CAS NO 948564-73-6 is a fully human monoclonal antibody that functions as a potent and specific neutralizing agent for all isoforms of transforming growth factor-beta (TGF-β). This compound is of significant value in advanced biomedical research and therapeutic development due to its ability to precisely modulate the TGF-β signaling pathway, which is implicated in a wide range of biological processes. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on oncology, immunology, and fibrotic diseases.

Application

• Oncology Research: Investigation of TGF-β's role in tumor progression, metastasis, and the tumor microenvironment.
• Therapeutic Antibody Development: Serves as a reference standard or a key intermediate in the development of novel biologic therapies.
• Immunology Studies: Used to study immune regulation, T-cell differentiation, and autoimmune disease mechanisms.
• Fibrosis Research: Exploration of therapeutic strategies for conditions like pulmonary fibrosis, liver fibrosis, and systemic sclerosis.
• Cell Culture & In Vitro Assays: Employed to inhibit TGF-β activity in specialized cell-based experiments.
• Preclinical Model Validation: Critical for validating animal models of cancer and fibrotic diseases where TGF-β signaling is a target.

Basic Information

Product Name	Fresolimumab
CAS No.	948564-73-6
Molecular Formula	Contact for details
Molecular Weight	Approx. 145 kDa
Synonyms	GC1008; Anti-TGF-β 1,2,3 Antibody; TGF-β Neutralizing Antibody; Human Anti-TGFβ Monoclonal Antibody; TGF-beta 1,2,3 Inhibitor; Fresolimumab (GC1008); Monoclonal Antibody to TGF-β
EINECS	Contact for details

Quality Control

Our Fresolimumab is produced and handled under stringent quality management systems. Each batch undergoes rigorous analytical testing, including purity assessment by HPLC, identity confirmation, and biological activity assays, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive) and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE & SEC-HPLC)	> 95%
Protein Content (UV/A280)	As per COA
Endotoxin Level (LAL)	< 1.0 EU/mg
Biological Activity (Cell-based Assay)	Conforms to reference
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.