Description

5-Isocyanato-2-Trifluoromethyl-Pyridine is a specialized heterocyclic building block featuring both an isocyanate group and a trifluoromethyl substituent on a pyridine ring. This unique molecular architecture makes it a high-value intermediate for introducing the pyridine-trifluoromethyl pharmacophore and enabling further derivatization via the reactive isocyanate moiety. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the biological activity of the trifluoromethylpyridine moiety.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers, such as polyurethanes and polyureas with unique thermal or chemical resistance.
• Chemical Biology & Proteomics: Utilized as a reactive handle for bioconjugation, labeling proteins, or creating activity-based probes for enzyme studies.
• Ligand & Catalyst Development: Acts as a precursor for synthesizing sophisticated ligands used in catalysis or metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A critical raw material for fine chemical manufacturers offering bespoke synthesis services for clients in life sciences.

Basic Information

Product Name	5-Isocyanato-2-Trifluoromethyl-Pyridine
CAS No.	948551-74-4
Molecular Formula	C7H3F3N2O
Molecular Weight	188.11 g/mol
Synonyms	2-(Trifluoromethyl)pyridine-5-isocyanate; 5-Isocyanato-2-(trifluoromethyl)pyridine; 2-Trifluoromethyl-5-pyridyl isocyanate; 5-Pyridineisocyanate, 2-(trifluoromethyl)-; 2-Trifluoromethylpyridin-5-yl isocyanate
EINECS	Contact for details

Quality Control

Every batch of 5-Isocyanato-2-Trifluoromethyl-Pyridine is produced and analyzed under strict quality management protocols. We ensure high purity and consistency through advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.