Description

(4S,Cis)-1,1-Dimethylethyl-6-Aminoethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetate is a high-purity, chiral building block and advanced pharmaceutical intermediate. This compound is valued for its defined stereochemistry, which is critical for synthesizing active pharmaceutical ingredients (APIs) with specific biological activity. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development and production of novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers with high enantiomeric purity.
• Peptidomimetic Research: Serves as a constrained scaffold or backbone component in the design and synthesis of peptide analogs and mimetics for drug discovery.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable manufacturing of target compounds under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probes: Utilized in the construction of molecular probes for studying enzyme mechanisms or protein-ligand interactions.

Basic Information

Product Name	(4S,Cis)-1,1-Dimethylethyl-6-Aminoethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetate
CAS No.	947586-93-8
Molecular Formula	C15H29NO4
Molecular Weight	287.40 g/mol
Synonyms	(4S,6S)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester; tert-Butyl (4S,6S)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate; (4S,6S)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester; (4S-cis)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester; Boc-protected amino dioxane derivative; Chiral 1,3-dioxane acetate intermediate
EINECS	Contact for details

Quality Control

Our (4S,Cis)-1,1-Dimethylethyl-6-Aminoethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.