Description

5,8-Dioxa-2-Aza-Spiro[3.4]Octane, Hydrochloride is a high-value, heterocyclic building block featuring a unique spirocyclic structure that incorporates both ether and amine functionalities. This compound is of significant interest in advanced organic synthesis, particularly for the construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing spirocyclic scaffolds in drug discovery programs targeting CNS disorders, infectious diseases, and metabolic conditions.
• Medicinal Chemistry Building Block: Used to introduce conformational constraint and modulate physicochemical properties like solubility and metabolic stability in lead optimization.
• Agrochemical Synthesis: Serves as a precursor for developing novel herbicides, fungicides, or insecticides with new modes of action.
• Ligand and Catalyst Development: The nitrogen and oxygen atoms can act as coordination sites for metals in catalytic systems or as part of specialized ligands.
• Material Science Research: Potential monomer or cross-linking agent for creating polymers with specific thermal or mechanical properties.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic synthesis, exploring new ring-forming reactions and heterocyclic chemistry.

Basic Information

Product Name	5,8-Dioxa-2-Aza-Spiro[3.4]Octane, Hydrochloride
CAS No.	947533-98-4
Molecular Formula	C6H10ClNO2
Molecular Weight	163.60 g/mol
Synonyms	2-Aza-5,8-dioxaspiro[3.4]octane hydrochloride; 5,8-Dioxa-2-azaspiro[3.4]octane HCl; 1-Oxa-4-azaspiro[4.3]hexane, 6-oxa-, hydrochloride (9CI); Spiro[3.4]octane, 5,8-dioxa-2-aza-, hydrochloride; 2-Azaspiro[3.4]octane-5,8-dione hydrochloride (tautomeric form); 5,8-Dioxa-2-azaspiro[3.4]octan-2-ium chloride
EINECS	Contact for details

Quality Control

Our 5,8-Dioxa-2-Aza-Spiro[3.4]Octane, Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring consistency and traceability suitable for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.