Description

2-((Trimethylsilyl)Ethynyl)Pyridin-3-Amine is a high-value, functionalized pyridine derivative featuring a trimethylsilyl-protected ethynyl group, which serves as a versatile synthetic handle for further chemical elaboration. This compound is crucial for advanced organic synthesis, particularly in the construction of complex heterocyclic scaffolds and functional materials. It is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and material science industries for use as a key building block in drug discovery and specialty chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of advanced polymers, conductive materials, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The ethynyl group is a prime substrate for Sonogashira, Glaser, and other palladium-catalyzed cross-coupling reactions to create complex molecular architectures.
• Ligand Synthesis: Used to prepare novel nitrogen-containing ligands for catalysis and coordination chemistry.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological systems.

Basic Information

Product Name	2-((Trimethylsilyl)Ethynyl)Pyridin-3-Amine
CAS No.	947330-64-5
Molecular Formula	C10H16N2Si
Molecular Weight	192.34 g/mol
Synonyms	3-Amino-2-((trimethylsilyl)ethynyl)pyridine; 2-((Trimethylsilyl)ethynyl)-3-pyridinamine; 2-Ethynyl-3-aminopyridine, TMS-protected; 3-Pyridinamine, 2-[(trimethylsilyl)ethynyl]-; TMS-Ethynyl-3-aminopyridine; 2-(Trimethylsilylethynyl)pyridin-3-amine; 2-(2-Trimethylsilylethynyl)-3-aminopyridine
EINECS	Contact for details

Quality Control

Our 2-((Trimethylsilyl)Ethynyl)Pyridin-3-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to supply chain reliability and documentation transparency supports your R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.