Description

1H-Pyrrole-3-Carboxylic Acid, 2-[1-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-1-Methylethyl]-5-(4-Pyridinyl)- is a sophisticated heterocyclic building block featuring a pyrrole core substituted with a carboxylic acid group, a tert-butoxycarbonyl (Boc)-protected amino isopropyl moiety, and a 4-pyridinyl group. This compound matters as a high-value, multi-functional intermediate designed for advanced synthetic chemistry, enabling the construction of complex molecular architectures. It is primarily needed by pharmaceutical R&D and agrochemical organizations for developing novel active ingredients, particularly in medicinal chemistry programs targeting kinase inhibitors and other biologically relevant scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for kinase inhibitor libraries and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile functional groups (Boc-protected amine, carboxylic acid, heteroaromatic rings).
• Agrochemical Synthesis: Serves as a precursor for developing novel crop protection agents and pesticides with enhanced efficacy.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences industry.
• Academic Research: Employed in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Item	Details
Product Name	1H-Pyrrole-3-Carboxylic Acid, 2-[1-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-1-Methylethyl]-5-(4-Pyridinyl)-
CAS No.	947327-48-2
Molecular Formula	C20H25N3O4
Molecular Weight	371.43 g/mol
Synonyms	2-(2-((tert-Butoxycarbonyl)amino)propan-2-yl)-5-(pyridin-4-yl)-1H-pyrrole-3-carboxylic acid; 2-(1-((tert-Butoxycarbonyl)amino)-1-methylethyl)-5-(4-pyridinyl)-1H-pyrrole-3-carboxylic acid; 5-(Pyridin-4-yl)-2-[2-({[(tert-butoxy)carbonyl]amino}methyl)propan-2-yl]-1H-pyrrole-3-carboxylic acid; tert-Butyl N-[1-(5-carboxy-5-(4-pyridyl)-1H-pyrrol-2-yl)-1-methyl-ethyl]carbamate; Boc-protected pyrrole-pyridine carboxylic acid; 947327-48-2
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for advanced pharmaceutical intermediates. We employ validated analytical methods, including HPLC, NMR, and MS, to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are available upon request. Our quality management system supports development under cGMP guidelines as required for pre-clinical and clinical-stage materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.