Description

3-(Difluoromethoxy)Pyridin-2-Amine is a high-value pyridine derivative featuring a difluoromethoxy substituent, a key structural motif prized for its ability to modulate the physicochemical properties of active molecules. This compound serves as a critical advanced pharmaceutical intermediate and versatile building block in modern synthetic chemistry. It is primarily utilized by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and synthesis of new drug candidates, particularly in areas like kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used as a building block for developing advanced herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Ligand & Catalyst Development: Employed in the creation of novel ligands for catalysis and metal-organic frameworks (MOFs) due to its nitrogen-containing heterocyclic structure.
• Material Science Research: Serves as a precursor for functionalized polymers and advanced organic electronic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up.
• Academic & Industrial R&D: Used in research laboratories for methodological studies and exploring new chemical spaces in medicinal and synthetic chemistry.

Basic Information

Product Name	3-(Difluoromethoxy)Pyridin-2-Amine
CAS No.	947249-14-1
Molecular Formula	C6H6F2N2O
Molecular Weight	160.12 g/mol
Synonyms	2-Amino-3-(difluoromethoxy)pyridine; 3-(Difluoromethoxy)-2-pyridinamine; 2-Pyridinamine, 3-(difluoromethoxy)-; 3-Difluoromethoxypyridin-2-ylamine; 947249-14-1; 3-(Difluoromethoxy)-2-aminopyridine; 2-Amino-3-difluoromethoxypyridine
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)Pyridin-2-Amine is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.