Description

2-Amino-3-difluoromethoxy-5-bromopyridine is a high-value brominated and fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and difluoromethoxy substituents, makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the difluoromethoxy and bromine groups can contribute to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized nitrogen-containing ligands used in catalytic systems and coordination chemistry.
• Material Science Research: Employed in the synthesis of functionalized organic materials and liquid crystals, where halogen and fluorine atoms modify electronic and physical properties.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	2-Amino-3-difluoromethoxy-5-bromopyridine
CAS No.	947249-13-0
Molecular Formula	C6H5BrF2N2O
Molecular Weight	239.02 g/mol
Synonyms	5-Bromo-3-(difluoromethoxy)pyridin-2-amine; 5-Bromo-3-difluoromethoxypyridin-2-amine; 2-Amino-5-bromo-3-(difluoromethoxy)pyridine; 3-Difluoromethoxy-5-bromopyridin-2-amine; 947249-13-0; 2-Pyridinamine, 5-bromo-3-(difluoromethoxy)-
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-3-difluoromethoxy-5-bromopyridine is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent batch-to-batch quality. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.