Description

2-Amino-3-(Trifluoromethyl)Pyridine-5-Boronic Acid Pinacol Ester is a high-value, multifunctional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone method for constructing complex molecules. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional molecules. The CAS number for this product is 947249-01-6.

Application

This versatile boronic ester is a key intermediate in the synthesis of complex heterocyclic compounds. Its primary applications include:

• Pharmaceutical Intermediates: Critical for constructing active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Serves as a building block for organic light-emitting diodes (OLEDs), liquid crystals, and conductive polymers.
• Chemical Biology & Proteomics: Employed in the development of molecular probes, bioconjugates, and activity-based protein profiling (ABPP) reagents.
• Catalyst & Ligand Development: Used to synthesize novel nitrogen-containing ligands for transition metal catalysis.
• Custom Synthesis & Contract Research: A fundamental reagent for CROs and CDMOs engaged in custom synthesis and library production for clients.

Basic Information

Product Name	2-Amino-3-(Trifluoromethyl)Pyridine-5-Boronic Acid Pinacol Ester
CAS No.	947249-01-6
Molecular Formula	C₁₂H₁₆BF₃N₂O₂
Molecular Weight	288.08 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridin-2-amine; 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridine; 3-(Trifluoromethyl)-2-amino-5-pyridineboronic acid pinacol ester; 2-Amino-3-trifluoromethyl-5-pyridineboronic acid pinacol ester; Pinacol [2-amino-3-(trifluoromethyl)pyridin-5-yl]boronate; B-[2-Amino-3-(trifluoromethyl)-5-pyridinyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 947249-01-6
EINECS	Contact for details

Quality Control

Our 2-Amino-3-(Trifluoromethyl)Pyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent hydrolysis and maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.