Description

3-Ethoxycarbonyl-1H-Indazole-6-Boronic Acid Pinacol Ester is a high-value, protected boronic acid derivative essential for modern synthetic organic chemistry. This compound matters as a critical building block in cross-coupling reactions, enabling the precise construction of complex molecular architectures. Pharmaceutical, agrochemical, and advanced materials researchers need it for developing new active ingredients and functional molecules. Its stability and reactivity profile make it a preferred reagent for Suzuki-Miyaura coupling in complex synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel indazole-based drug candidates, including kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in creating new active ingredients for crop protection with enhanced efficacy and environmental profiles.
• Suzuki-Miyaura Cross-Coupling: A crucial reagent for forming carbon-carbon bonds in the synthesis of complex biaryl and heterobiaryl structures.
• Material Science: Serves as a precursor for organic electronic materials, such as OLEDs and organic semiconductors.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized in the development of bifunctional molecules for targeted protein degradation.
• Academic & Contract Research: A valuable tool for methodology development and library synthesis in medicinal chemistry programs.

Basic Information

Product Name	3-Ethoxycarbonyl-1H-Indazole-6-Boronic Acid Pinacol Ester
CAS No.	947191-20-0
Molecular Formula	C₁₆H₂₁BN₂O₄
Molecular Weight	316.16 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-3-carboxylic acid ethyl ester; Ethyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-3-carboxylate; 1H-Indazole-3-carboxylic acid, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, ethyl ester; 3-Carbethoxy-6-boronic acid pinacol ester indazole; 947191-20-0; Boric acid, B-[3-(ethoxycarbonyl)-1H-indazol-6-yl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 3-Ethoxycarbonyl-1H-Indazole-6-Boronic Acid Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) with full analytical data are available upon request. We support compliance needs for cGMP, ISO, and other relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.