Description

1H-Indazole-3-Carboxylic Acid, 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Ethyl Ester is a high-value, multi-functional boronic ester derivative of indazole, serving as a critical synthetic intermediate. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl and heterobiaryl scaffolds. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-inflammatory research programs.
• Medicinal Chemistry: Enables the rapid exploration of structure-activity relationships (SAR) by facilitating the introduction of diverse aryl and heteroaryl groups at the 5-position of the indazole core.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that incorporate the indazole pharmacophore.
• Material Science: Potential precursor for organic electronic materials, ligands for catalysis, and metal-organic frameworks (MOFs).
• Chemical Biology: Employed in the synthesis of molecular probes and labeled compounds for biochemical assays and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring advanced boronic ester chemistry.

Basic Information

Product Name	1H-Indazole-3-Carboxylic Acid, 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Ethyl Ester
CAS No.	947191-19-7
Molecular Formula	C₁₆H₂₁BN₂O₄
Molecular Weight	316.16 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-3-carboxylic acid ethyl ester; Ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-3-carboxylate; 1H-Indazole-3-carboxylic acid, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, ethyl ester; 947191-19-7; 5-Pinacolatoboryl-1H-indazole-3-carboxylic acid ethyl ester; Ethyl 5-(pinacolatoboryl)-1H-indazole-3-carboxylate; Boronic acid, B-[3-(ethoxycarbonyl)-1H-indazol-5-yl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 1H-Indazole-3-Carboxylic Acid, 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, we recommend keeping the product at 2-8°C under an inert atmosphere to maintain optimal stability and prevent degradation of the boronic ester functionality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.