Description

(1R,2S)-1'-Methyl-2'-Oxospiro[Cyclohexane-1,3'-Indoline]-2-Carbonitrile is a high-purity, chiral spirocyclic indoline derivative. This compound serves as a critical advanced intermediate in modern pharmaceutical synthesis, enabling the development of novel therapeutic agents. It is primarily required by research institutions and pharmaceutical companies engaged in the development of complex small-molecule drugs, particularly those targeting central nervous system disorders and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs) with spirocyclic or indoline motifs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Asymmetric Synthesis: Employed as a precursor or scaffold in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Process Chemistry Development: Serves as a model compound for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	(1R,2S)-1'-Methyl-2'-Oxospiro[Cyclohexane-1,3'-Indoline]-2-Carbonitrile
CAS No.	947184-94-3
Molecular Formula	C16H18N2O
Molecular Weight	254.33 g/mol
Synonyms	(1R,2S)-1'-Methylspiro[cyclohexane-1,3'-indoline]-2'-one-2-carbonitrile; (1R,2S)-1-Methyl-2-oxospiro[cyclohexane-1,3'-indoline]-2-carbonitrile; (1R,2S)-1'-Methyl-2-oxospiro[cyclohexane-1,3'-indoline]-2-carbonitrile; Spiro[cyclohexane-1,3'-indoline]-2-carbonitrile, 1'-methyl-2'-oxo-, (1R,2S)-; 947184-94-3; (1R,2S)-enantiomer of 1'-Methyl-2'-oxospiro[cyclohexane-1,3'-indoline]-2-carbonitrile
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) are available upon request, detailing comprehensive specifications including assay, chiral purity, and impurity profiles. We adhere to a strict quality management system to ensure batch-to-batch consistency for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.