Description

(1R,2R)-1'-Methyl-2'-Oxospiro[Cyclohexane-1,3'-Indoline]-2-Carbonitrile is a high-purity, chiral spirocyclic indoline derivative. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) and a versatile chiral building block in organic synthesis. It is essential for research and development in the pharmaceutical and agrochemical industries, particularly for the synthesis of complex molecules with specific stereochemistry. Our supply is characterized by consistent quality and reliable batch-to-batch reproducibility.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Asymmetric Synthesis Building Block: Used in the construction of complex, stereochemically defined molecular architectures due to its rigid spirocyclic framework.
• Agrochemical Research: Employed in the development of new chiral active ingredients for crop protection with enhanced efficacy.
• Catalyst & Ligand Development: Serves as a scaffold for creating novel chiral catalysts and ligands for enantioselective transformations.
• Academic & Industrial R&D: A valuable compound for methodological studies in synthetic organic chemistry and medicinal chemistry programs.
• Fine Chemical Production: Used in the multi-step synthesis of specialty chemicals requiring high stereochemical purity.

Basic Information

Product Name	(1R,2R)-1'-Methyl-2'-Oxospiro[Cyclohexane-1,3'-Indoline]-2-Carbonitrile
CAS No.	947184-93-2
Molecular Formula	C16H18N2O
Molecular Weight	254.33 g/mol
Synonyms	(1R,2R)-1'-Methyl-2-oxospiro[cyclohexane-1,3'-indoline]-2-carbonitrile; (1R,2R)-1-Methyl-2-oxospiro[cyclohexane-1,3'-indoline]-2-carbonitrile; Spiro[cyclohexane-1,3'-indoline]-2-carbonitrile, 1'-methyl-2'-oxo-, (1R,2R)-; (1R,2R)-1'-Methylspiro[cyclohexane-1,3'-indoline]-2'-one-2-carbonitrile; (1R,2R)-1-Methyl-2-oxo-2,3-dihydrospiro[indole-3,1'-cyclohexane]-2-carbonitrile
EINECS	Contact for details

Quality Control

Our (1R,2R)-1'-Methyl-2'-Oxospiro[Cyclohexane-1,3'-Indoline]-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.