Description

(1R,2S)-1'-Methyl-2'-Oxospiro[Cyclopentane-1,3'-Indoline]-2-Carbonitrile is a high-purity, chiral spirocyclic indoline derivative of significant interest in advanced organic synthesis. This compound serves as a critical and versatile pharmaceutical intermediate for constructing complex molecular architectures. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, especially those with spirocyclic or indoline-based scaffolds.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce complex, three-dimensional chirality into target molecules.
• Medicinal Chemistry Research: Serves as a core structure for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for potential APIs under Good Manufacturing Practice (GMP) considerations.
• Chemical Biology Probes: Acts as a precursor for developing tool compounds to study biological pathways and protein functions.

Basic Information

Item	Details
Product Name	(1R,2S)-1'-Methyl-2'-Oxospiro[Cyclopentane-1,3'-Indoline]-2-Carbonitrile
CAS No.	947184-92-1
Molecular Formula	C15H16N2O
Molecular Weight	240.30 g/mol
Synonyms	(1R,2S)-1'-Methylspiro[cyclopentane-1,3'-indoline]-2'-one-2-carbonitrile; (1R,2S)-1'-Methyl-2-oxospiro[cyclopentane-1,3'-indoline]-2-carbonitrile; Spiro[cyclopentane-1,3'-indoline]-2-carbonitrile, 1'-methyl-2'-oxo-, (1R,2S)-; (1R,2S)-1'-Methyl-2'-oxo-1,2-dihydrospiro[cyclopentane-1,3'-indole]-2-carbonitrile
EINECS	Contact for details

Quality Control

We supply this advanced intermediate under a strict quality management system. Each batch is characterized and tested to ensure identity, purity, and chiral integrity, with specifications tailored to research or development needs. A comprehensive Certificate of Analysis (COA) is provided, detailing results from analytical methods including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry. Our quality commitment supports your regulatory filings from discovery through development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be sensitive to moisture and prolonged exposure to air; consider storage under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.