Description

(1R,2R)-1'-Methyl-2'-Oxospiro[Cyclopentane-1,3'-Indoline]-2-Carbonitrile is a high-purity chiral spirocyclic compound with significant synthetic utility. This advanced pharmaceutical intermediate is valued for its complex molecular architecture, which serves as a key building block in the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of complex molecules for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Asymmetric Synthesis: Used as a key starting material or intermediate in complex asymmetric synthesis routes due to its defined stereochemistry.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Process Chemistry Development: Serves as a reference standard or intermediate for scaling up synthetic routes from laboratory to pilot plant scale.
• Catalyst and Ligand Synthesis: Potential precursor for the development of novel chiral catalysts or ligands used in enantioselective transformations.
• Academic Research: Utilized in university and institutional labs for methodological studies in organic and heterocyclic chemistry.

Basic Information

Product Name	(1R,2R)-1'-Methyl-2'-Oxospiro[Cyclopentane-1,3'-Indoline]-2-Carbonitrile
CAS No.	947184-91-0
Molecular Formula	C15H16N2O
Molecular Weight	240.30 g/mol
Synonyms	(1R,2R)-1'-Methyl-2-oxospiro[cyclopentane-1,3'-indoline]-2-carbonitrile; (1R,2R)-1'-Methylspiro[cyclopentane-1,3'-indoline]-2'-one-2-carbonitrile; Spiro[cyclopentane-1,3'-indoline]-2-carbonitrile, 1'-methyl-2'-oxo-, (1R,2R)-; (1R,2R)-1'-Methyl-2'-oxo-1,3-dihydrospiro[indene-2,2'-cyclopentane]-1-carbonitrile (alternative ring numbering); (R,R)-1'-Methyl-2'-oxospiro[cyclopentane-1,3'-indoline]-2-carbonitrile
EINECS	Contact for details

Quality Control

Our (1R,2R)-1'-Methyl-2'-Oxospiro[Cyclopentane-1,3'-Indoline]-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and enantiomeric excess meet the highest standards for pharmaceutical R&D. Certificates of Analysis (COA) detailing chiral purity, assay, and impurity profiles are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.