Description

2-Pyridinecarboxamide, n-(2-Chloro-4-Pyridinyl)-6-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multi-functional boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecular architectures through efficient cross-coupling reactions. This advanced intermediate is essential for research and development teams in the pharmaceutical and agrochemical industries, particularly those focused on creating novel active ingredients. Its specific structure makes it a sought-after reagent for medicinal chemistry programs targeting new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• Agrochemical Synthesis: Serves as a building block for creating advanced crop protection agents and pesticides with improved efficacy.
• Material Science: Potential use in the synthesis of organic electronic materials and functional polymers requiring specific boronate functionalities.
• Chemical Biology Probes: Employed in the development of molecular probes and tools for studying biological processes and target identification.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Pyridinecarboxamide, n-(2-Chloro-4-Pyridinyl)-6-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	947179-31-9
Molecular Formula	C18H21BClN3O3
Molecular Weight	373.64 g/mol
Synonyms	N-(2-Chloro-4-pyridinyl)-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinecarboxamide; 6-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2-chloropyridin-4-yl)picolinamide; 947179-31-9; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2-chloro-4-pyridinyl)-6-methyl-2-pyridinecarboxamide; Boronic acid, B-[6-[[(2-chloro-4-pyridinyl)amino]carbonyl]-2-methyl-3-pyridinyl]-, 1,3-propanediol cyclic ester; (6-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)(2-chloropyridin-4-yl)methanone
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and reliability for your critical synthesis workflows. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay, identity, and impurity profiles. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.