Description

Piromelatine is a high-purity synthetic compound of significant interest in advanced pharmaceutical research and development. Its primary value lies in its role as a potent and selective agonist for the melatonin MT1 and MT2 receptors, which are key targets for modulating sleep-wake cycles and circadian rhythms. This makes it a critical intermediate for researchers and manufacturers developing novel therapeutics for sleep disorders, depression, and other neurological conditions. Global pharmaceutical companies, contract research organizations (CROs), and fine chemical suppliers require a reliable source of this material to support their preclinical and clinical development pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs) targeting neurological pathways.
• Neuropharmacology Research: Used as a reference standard and experimental compound in studies investigating sleep regulation, circadian biology, and mood disorders.
• Drug Discovery & Development: Employed in high-throughput screening and lead optimization programs focused on melatonin receptor agonists.
• Preclinical Studies: Essential for pharmacokinetic, pharmacodynamic, and toxicology evaluations in animal models.
• Reference Standard: Utilized in analytical laboratories for method development, validation, and quality control of related substances.
• Clinical Trial Material (CTM) Manufacturing: Supplied under controlled conditions for the production of batches used in human clinical trials.

Basic Information

Product Name	Piromelatine
CAS No.	946846-83-9
Molecular Formula	C23H26N4O2
Molecular Weight	390.48 g/mol
Synonyms	AGN-2979; Piromelatine; N-[2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]propionamide; 8-[2-(Propionylamino)ethyl]-6,7-dihydro-4H-indeno[5,4-b]furan; AGN 2979; MT1/MT2 receptor agonist; Circadin analogue
EINECS	Contact for details

Quality Control

Every batch of Piromelatine is manufactured and tested under a strict quality management system to ensure it meets the exacting standards required for pharmaceutical research. Our products undergo rigorous quality testing, including identity confirmation, purity assay, and impurity profiling, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing all test results are available upon request, providing full traceability and supporting regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.