Description

Probarbital CAS NO 143-82-8 is a short-acting barbiturate derivative, a class of compounds historically significant in medicinal chemistry for their central nervous system depressant effects. Its precise chemical structure makes it a valuable reference standard and a key intermediate in pharmaceutical research and development. This compound is primarily utilized by research institutions, analytical laboratories, and pharmaceutical companies engaged in method development, quality control, and the synthesis of specialized therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control testing in compliance with pharmacopeial guidelines (e.g., USP, EP).
• Biochemical Research: Serves as a tool compound in neuroscience and pharmacology studies to investigate GABAA receptor modulation and sedative-hypnotic mechanisms.
• Chemical Synthesis Intermediate: Acts as a crucial building block for the preparation of more complex barbiturate analogs and related heterocyclic compounds.
• Forensic and Clinical Toxicology: Employed as a calibrant or control in analytical assays to detect and quantify barbiturates in biological matrices.
• Academic Research & Teaching: Used in university laboratories for educational purposes in advanced organic chemistry and medicinal chemistry courses.

Basic Information

Product Name	Probarbital
CAS No.	143-82-8
Molecular Formula	C9H14N2O3
Molecular Weight	198.22 g/mol
Synonyms	5-Ethyl-5-(1-methylpropyl)barbituric acid; 5-Ethyl-5-sec-butylbarbituric acid; Probarbital sodium (salt form); Ipral; Etallymal; Meballymal; NSC 7495
EINECS	205-617-9

Quality Control

Our Probarbital is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and impurity profiling, to ensure it meets high-purity standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.