Description

1,3-Dihydro-7-Chloro-1-[3-(Dimethylamino)Propyl]-5-Phenyl-2H-1,4-Benzodiazepin-2-One is a high-purity benzodiazepine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical pharmaceutical intermediate for the synthesis of active pharmaceutical ingredients (APIs) and novel therapeutic agents. It is primarily sought by pharmaceutical manufacturers and contract research organizations (CROs) engaged in the development of central nervous system (CNS) medications and other specialized drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex benzodiazepine-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the discovery and development of new therapeutic agents targeting the central nervous system.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Preclinical Studies: Employed in pharmacological and toxicological studies to investigate the properties of novel benzodiazepine analogs.
• Chemical Synthesis: Utilized in organic synthesis for creating specialized libraries of compounds for biological screening.

Basic Information

Product Name	1,3-Dihydro-7-Chloro-1-[3-(Dimethylamino)Propyl]-5-Phenyl-2H-1,4-Benzodiazepin-2-One
CAS No.	1100-25-0
Molecular Formula	C20H22ClN3O
Molecular Weight	355.86 g/mol
Synonyms	7-Chloro-1-[3-(dimethylamino)propyl]-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Chloro-1-(3-dimethylaminopropyl)-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; Ro 05-2921; Ro 5-2921; Ro05-2921; Ro5-2921; 1100-25-0; 1,4-Benzodiazepin-2-one, 7-chloro-1-[3-(dimethylamino)propyl]-1,3-dihydro-5-phenyl-
EINECS	214-158-3

Quality Control

Our 1,3-Dihydro-7-Chloro-1-[3-(Dimethylamino)Propyl]-5-Phenyl-2H-1,4-Benzodiazepin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards expected for pharmaceutical-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat and incompatible materials. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.