Description

3-Amino-6-(Trifluoromethyl)Picolinamide is a high-purity, multi-functional heterocyclic building block featuring both an amino and an amide group on a trifluoromethylated pyridine core. This compound matters for its unique trifluoromethyl group, which is a critical pharmacophore known to enhance metabolic stability, lipophilicity, and bioavailability in active molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small molecule drugs, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing CF3 group.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing molecular probes, enzyme inhibitors, and tool compounds for target validation.
• Material Science Research: Investigated as a precursor for specialty polymers, ligands for catalysis, and components in organic electronic materials.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and scale-up projects under cGMP or ISO quality systems.

Basic Information

Product Name	3-Amino-6-(Trifluoromethyl)Picolinamide
CAS No.	946594-91-8
Molecular Formula	C7H6F3N3O
Molecular Weight	205.14 g/mol
Synonyms	3-Amino-6-(trifluoromethyl)pyridine-2-carboxamide; 2-Pyridinecarboxamide, 3-amino-6-(trifluoromethyl)-; 6-(Trifluoromethyl)-3-aminopicolinamide; 3-Amino-6-trifluoromethylpicolinamide; 3-Amino-6-(trifluoromethyl)-2-pyridinecarboxamide; 3-Amino-6-(trifluoromethyl)-2-carbamoylpyridine; 946594-91-8
EINECS	Contact for details

Quality Control

Our 3-Amino-6-(Trifluoromethyl)Picolinamide is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing results from HPLC, NMR, and MS. Our quality commitment supports applications requiring high-purity intermediates for research and development under ISO and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.