Description

3-Amino-6-(Trifluoromethyl)Pyridine-2-Carbonitrile is a high-value, multi-functional heterocyclic building block featuring both amino and nitrile functional groups on a trifluoromethylated pyridine core. This compound is essential for medicinal chemistry and agrochemical research, enabling the rapid synthesis of complex molecules with enhanced biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and crop protection industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, receptor antagonists, and other small-molecule drug candidates, leveraging the trifluoromethyl group for improved lipophilicity and bioavailability.
• Agrochemical Synthesis: Used in constructing advanced fungicides, herbicides, and insecticides where the pyridine scaffold contributes to target specificity and environmental persistence.
• Material Science Precursor: Serves as a starting material for functionalized ligands in catalysis or for creating specialty polymers with unique electronic properties.
• Chemical Biology Probe Development: Employed in synthesizing tagged molecules for studying biological pathways and protein interactions due to its reactive handles for further conjugation.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses serving the global life sciences sector, enabling the production of bespoke compounds for client pipelines.

Basic Information

Product Name	3-Amino-6-(Trifluoromethyl)Pyridine-2-Carbonitrile
CAS No.	946594-89-4
Molecular Formula	C7H4F3N3
Molecular Weight	187.12 g/mol
Synonyms	2-Cyano-3-amino-6-(trifluoromethyl)pyridine; 6-(Trifluoromethyl)-3-aminopicolinonitrile; 3-Amino-6-trifluoromethylpyridine-2-carbonitrile; 2-Pyridinecarbonitrile, 3-amino-6-(trifluoromethyl)-; 3-Amino-6-(trifluoromethyl)-2-pyridinecarbonitrile; 3-Amino-6-(trifluoromethyl)picolinonitrile; 3-Amino-6-(trifluoromethyl)-2-cyanopyridine
EINECS	Contact for details

Quality Control

Every batch of 3-Amino-6-(Trifluoromethyl)Pyridine-2-Carbonitrile is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for research and development use under cGMP guidelines where applicable. A detailed Certificate of Analysis (COA) providing batch-specific results for purity, impurities, and other critical parameters is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.