Description

5-(Chloromethyl)-2-(Difluoromethyl)Pyridine is a versatile and high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its bifunctional nature, featuring both a reactive chloromethyl group and a difluoromethyl substituent, makes it an indispensable intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides, leveraging the difluoromethyl group to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized pyridine-based ligands used in transition metal catalysis and material science.
• Fluorinated Building Block: Essential for introducing the difluoromethyl (CF2H) pharmacophore into molecules, a strategy widely used in modern medicinal chemistry to fine-tune properties like lipophilicity and metabolic stability.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating libraries of fluorinated compounds for screening.

Basic Information

Product Name	5-(Chloromethyl)-2-(Difluoromethyl)Pyridine
CAS No.	946578-34-3
Molecular Formula	C7H6ClF2N
Molecular Weight	177.58 g/mol
Synonyms	2-(Difluoromethyl)-5-(chloromethyl)pyridine; 5-(Chloromethyl)-2-difluoromethylpyridine; 2-Difluoromethyl-5-chloromethylpyridine; Pyridine, 5-(chloromethyl)-2-(difluoromethyl)-; (Chloromethyl)(2-difluoromethyl-5-pyridyl)methane
EINECS	Contact for details

Quality Control

Every batch of 5-(Chloromethyl)-2-(Difluoromethyl)Pyridine is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.