Description

Foralumab is a human monoclonal antibody targeting the CD3 receptor on T cells. This compound is of significant interest in the research and development of novel immunotherapies, particularly for autoimmune and inflammatory diseases. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on modulating T-cell activity for therapeutic purposes.

Application

• Immunotherapy Research: A key investigational agent for studying T-cell modulation in autoimmune conditions like multiple sclerosis and Crohn's disease.
• Preclinical Development: Used in animal models to evaluate efficacy, pharmacokinetics, and safety profiles of anti-CD3 therapies.
• Mechanistic Studies: Employed in vitro to elucidate signaling pathways and immune cell interactions mediated by the CD3/T-cell receptor complex.
• Biopharmaceutical Manufacturing: Serves as a reference standard or critical raw material in the development and quality control of biologic drug products.
• Diagnostic Reagent Development: Potential use in the creation of assays and kits for detecting or quantifying T-cell subsets and activation states.

Basic Information

Product Name	Foralumab
CAS No.	946415-64-1
Molecular Formula	Contact for details
Molecular Weight	Approx. 150 kDa (Monoclonal Antibody)
Synonyms	NI-0401; Anti-Human CD3 Monoclonal Antibody; TOL-101; hIgG1k Anti-CD3; Monoclonal Antibody to CD3; Anti-CD3 Antibody, Human; Anti-CD3 mAb; Anti-CD3e Antibody
EINECS	Contact for details

Quality Control

Our Foralumab is produced and tested under stringent quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, potency, and consistency. Certificates of Analysis (COA) are provided, detailing results for critical quality attributes such as purity by SEC-HPLC, endotoxin levels, and biological activity. We adhere to relevant GMP guidelines for research-grade biopharmaceuticals.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under controlled, dry conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (HPLC/MS)	Conforms to reference standard
Purity (SEC-HPLC)	≥ 95% (Monomer)
Protein Content	≥ 1.0 mg/mL (or as specified)
Endotoxin	< 1.0 EU/mg
Biological Activity (Cell-based assay)	Contact for details
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.