Description

2-(2,6-Dioxopiperidin-3-Yl)-4-Nitroisoindoline-1,3-Dione is a high-purity, advanced pharmaceutical intermediate belonging to the class of imide derivatives. This compound is of significant commercial importance as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting specific disease pathways. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of proprietary drug candidates and complex molecules.
• API Synthesis: Serves as a core scaffold or building block for the production of Active Pharmaceutical Ingredients, especially in oncology and immunology research.
• Biochemical Research: Used in laboratory settings for studying enzyme inhibition, protein degradation mechanisms (e.g., Proteolysis Targeting Chimeras - PROTACs), and structure-activity relationships (SAR).
• Process Development & Scale-up: Employed by CDMOs for process optimization, route scouting, and scaling from gram to kilogram quantities for clinical trial material supply.
• Reference Standard: Sourced for use as an analytical standard in quality control laboratories to ensure the identity and purity of final drug substances.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry projects and the discovery of new chemical entities.

Basic Information

Product Name	2-(2,6-Dioxopiperidin-3-Yl)-4-Nitroisoindoline-1,3-Dione
CAS No.	19171-18-7
Molecular Formula	C₁₃H₉N₃O₆
Molecular Weight	303.23 g/mol
Synonyms	4-Nitro-2-(2,6-dioxo-3-piperidinyl)isoindoline-1,3-dione; 4-Nitro-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; 3-(4-Nitro-1,3-dioxoisoindolin-2-yl)piperidine-2,6-dione; 2-(2,6-Dioxo-3-piperidyl)-4-nitro-isoindoline-1,3-dione; 4-Nitrothalidomide; 4-Nitro-thalidomide; 4-NT; 4-Nitro-EM-12
EINECS	Contact for details

Quality Control

Our 2-(2,6-Dioxopiperidin-3-Yl)-4-Nitroisoindoline-1,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, to ensure it meets exacting standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.