Description

(S)-Lisofylline CAS NO 100324-80-9 is the pharmacologically active S-enantiomer of lisofylline, a methylxanthine derivative known for its potent anti-inflammatory and immunomodulatory properties. This high-purity chiral compound is critical for advanced pharmaceutical research and development, particularly in targeting specific biological pathways with minimal off-target effects. It is primarily utilized by research institutions and pharmaceutical companies engaged in developing novel therapeutics for inflammatory diseases, autoimmune disorders, and ischemia-reperfusion injury.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel anti-inflammatory drug candidates.
• Biomedical Research: Used as a reference standard and active agent in preclinical studies investigating phosphatidic acid signaling and neutrophil-mediated inflammation.
• Immunology Studies: Applied in vitro and in vivo to study the modulation of cytokine production (e.g., TNF-α, IL-1β) and T-cell activation.
• Therapeutic Development for Autoimmune Conditions: Investigated for potential applications in diseases like rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
• Ischemia-Reperfusion Injury Research: Explored for its protective effects in models of stroke, myocardial infarction, and organ transplantation.
• Metabolic Disorder Research: Studied for its potential role in modulating insulin sensitivity and inflammatory pathways associated with metabolic syndrome.

Basic Information

Product Name	(S)-Lisofylline
CAS No.	100324-80-9
Molecular Formula	C13H18N4O3
Molecular Weight	278.31 g/mol
Synonyms	(S)-(-)-Lisofylline; (S)-1-(5-R-Hydroxyhexyl)-3,7-dimethylxanthine; (S)-1-(5-Hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione; LSF; (S)-Pentoxifylline metabolite; (S)-PTX metabolite; (S)-Enantiomer of Lisofylline
EINECS	Contact for details

Quality Control

Our (S)-Lisofylline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with in-house specifications tailored for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.