Description

Human Ifn-Alpha A CAS NO 105388-21-4 is a highly purified, recombinant protein belonging to the interferon-alpha family, a critical class of signaling cytokines. This product is essential for research and development in immunology, virology, and oncology, where precise biological activity is paramount. It is primarily utilized by pharmaceutical developers, academic research institutions, and biotechnology companies for applications ranging from cell-based assays to therapeutic candidate studies.

Application

• Biopharmaceutical Research & Development: Used as a reference standard, positive control, or active pharmaceutical ingredient (API) in the development of immunotherapies and antiviral drugs.
• Cell Culture & In Vitro Studies: Induces antiviral states and modulates immune responses in mammalian cell lines for studying host-pathogen interactions and immune signaling pathways.
• Assay Development & Validation: Serves as a critical component in the development and calibration of bioassays (e.g., antiviral assays, ELISA kits) to quantify biological activity.
• Cancer Research: Investigated for its antiproliferative and immunomodulatory effects in various oncology research models.
• Signal Transduction Studies: A key tool for elucidating the JAK-STAT signaling pathway and other interferon-stimulated gene (ISG) networks.
• Process Development & Scale-Up: Used in downstream process development for purification and formulation studies of biologic products.

Basic Information

Product Name	Human Ifn-Alpha A
CAS No.	105388-21-4
Molecular Formula	C860H1353N227O255S9
Molecular Weight	Approx. 19,400 Da
Synonyms	Interferon α-2a; IFN-α2a; Roferon-A; Recombinant Human Interferon Alpha A; Interferon alfa-2a; rHuIFN-αA; Leukocyte Interferon (recombinant); IFN-α A; Interferon, leukocyte (human clone pIFN-αA protein moiety reduced)
EINECS	Contact for details

Quality Control

Our Human Ifn-Alpha A is manufactured under strict quality systems. Each batch is subjected to a comprehensive battery of analytical tests to ensure identity, purity, potency, and safety, aligning with standards relevant for research and development use. Specifications typically include assessment by SDS-PAGE, RP-HPLC, SEC-HPLC, and endotoxin testing. A Certificate of Analysis (COA) detailing purity, biological activity (in IU/mg), and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure containers are sealed under anhydrous conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE, reduced)	≥ 95%
Purity (RP-HPLC)	≥ 98.0%
Biological Activity (Antiviral Assay)	≥ 2.0 x 108 IU/mg
Endotoxin	< 1.0 EU/μg
Moisture Content (KF)	< 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.