Description

3-(tert-Butyldimethylsilanyloxymethyl)-4-Chlorobenzylamine is a high-value, protected amine intermediate featuring a chlorobenzyl group and a tert-butyldimethylsilyl (TBDMS) ether protecting group. This compound matters for its role as a critical building block in the synthesis of complex organic molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists working on active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the chlorobenzyl moiety is a common structural feature.
• Peptide Mimetics & Conjugates: Serves as a protected amine component for constructing peptide-like structures or antibody-drug conjugates (ADCs).
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis or metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client projects.
• Academic & Institutional Research: Utilized in university and government labs for fundamental organic chemistry research and methodology development.

Basic Information

Product Name	3-(tert-Butyldimethylsilanyloxymethyl)-4-Chlorobenzylamine
CAS No.	946000-12-0
Molecular Formula	C14H24ClNOSi
Molecular Weight	285.89 g/mol
Synonyms	4-Chloro-3-(((tert-butyldimethylsilyl)oxy)methyl)benzylamine; 3-((tert-Butyldimethylsilyloxy)methyl)-4-chlorobenzylamine; 4-Chloro-3-((tert-butyldimethylsilyloxy)methyl)benzylamine; 3-(TBDMS-oxymethyl)-4-chlorobenzylamine; 4-Chloro-3-(((tert-butyldimethylsilyl)oxy)methyl)benzenemethanamine; 946000-12-0; 3-(tert-Butyldimethylsilanyloxymethyl)-4-chloro-benzenemethanamine
EINECS	Contact for details

Quality Control

Our 3-(tert-Butyldimethylsilanyloxymethyl)-4-Chlorobenzylamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment. We support development and commercial projects with material suitable for research and cGMP manufacturing, as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged manipulations or when dispensing from the original container to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (Titration)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.