Description

2-[[(tert-Butyldimethylsilyl)Oxy]Methyl]-4-Iodo-1,3-Thiazole is a high-value, organosilyl-protected heterocyclic building block designed for advanced synthetic chemistry. This compound matters as a versatile intermediate, offering chemists a protected hydroxymethyl handle and a reactive iodo site for selective cross-coupling and functionalization reactions. It is primarily needed by pharmaceutical, agrochemical, and advanced materials research organizations for the development of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel thiazole-containing drug candidates, particularly for targeted therapies.
• Agrochemical Research: Used in the development of new fungicides, herbicides, and insecticides that leverage the thiazole moiety for bioactivity.
• Cross-Coupling Reactions: The 4-iodo substituent serves as an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings to construct complex biaryl systems.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules or probes for studying biological pathways and target engagement.
• Material Science Precursor: Potential use in creating functionalized polymers or organic electronic materials with specific optoelectronic properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research labs for bespoke synthesis projects requiring protected, multifunctional intermediates.

Basic Information

Product Name	2-[[(tert-Butyldimethylsilyl)Oxy]Methyl]-4-Iodo-1,3-Thiazole
CAS No.	945933-46-0
Molecular Formula	C10H18INOSSi
Molecular Weight	355.31 g/mol
Synonyms	4-Iodo-2-(((tert-butyldimethylsilyl)oxy)methyl)thiazole; 2-(((tert-Butyldimethylsilyl)oxy)methyl)-4-iodothiazole; 4-Iodo-2-((tert-butyldimethylsilyloxy)methyl)thiazole; TBDMS-protected 4-iodothiazole-2-methanol; 2-[(tert-Butyldimethylsilyloxy)methyl]-4-iodo-1,3-thiazole; 4-Iodo-2-((TBDMS-oxy)methyl)thiazole
EINECS	Contact for details

Quality Control

Our 2-[[(tert-Butyldimethylsilyl)Oxy]Methyl]-4-Iodo-1,3-Thiazole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive compound from degradation and to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.