Description

2,8-Diazaspiro[4.5]Decan-3-One Hydrochloride is a high-purity, pharmaceutically relevant organic salt, widely recognized by its CAS number 945892-88-6. This compound serves as a critical synthetic intermediate and building block in modern medicinal chemistry, valued for its spirocyclic diaza scaffold. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, metabolic diseases, and other therapeutic areas.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its privileged spirocyclic structure.
• Chemical Biology Probes: Serves as a core scaffold for developing tool compounds and probes to study biological pathways and enzyme functions.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) in drug discovery programs.
• Process Chemistry & Scale-up: Used in route scouting and process development for the commercial-scale manufacturing of candidate drugs.

Basic Information

Product Name	2,8-Diazaspiro[4.5]Decan-3-One Hydrochloride
CAS No.	945892-88-6
Molecular Formula	C8H15N2O • HCl
Molecular Weight	206.68 g/mol
Synonyms	2,8-Diazaspiro[4.5]decan-3-one, hydrochloride; 3-Oxo-2,8-diazaspiro[4.5]decane hydrochloride; 2,8-Diazaspiro[4.5]decan-3-one HCl; 2,8-Diazaspiro[4.5]decan-3-one monohydrochloride; Spiro[4.5]decane-8,2'-imidazolidin]-3'-one hydrochloride; 945892-88-6; 2,8-Diaza-spiro[4.5]decan-3-one hydrochloride
EINECS	Contact for details

Quality Control

Our 2,8-Diazaspiro[4.5]Decan-3-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.