Description

1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Ethyl Ester is a high-value boronic ester derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to construct complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing the privileged 7-azaindole (pyrrolopyridine) core.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronate ester coupling partner for the palladium-catalyzed introduction of the 4-substituted 7-azaindole moiety into complex molecules.
• Kinase Inhibitor Development: Critical precursor in the synthesis of targeted kinase inhibitors for oncology and other therapeutic areas, where the 7-azaindole scaffold is a common pharmacophore.
• Agrochemical Research: Used in the discovery and development of novel herbicides, fungicides, and insecticides with complex heterocyclic structures.
• Material Science & OLEDs: Employed in the synthesis of organic semiconductors, ligands for catalysts, and electron-transport materials for organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Useful linker or warhead component in the design of bifunctional molecules for targeted protein degradation.

Basic Information

Item	Details
Product Name	1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Ethyl Ester
CAS No.	945865-21-4
Molecular Formula	C16H21BN2O4
Molecular Weight	316.16 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester; Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate; 4-BPin-7-azaindole-2-carboxylic acid ethyl ester; 7-Azaindole-4-boronic acid pinacol ester, 2-ethoxycarbonyl-; 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, ethyl ester; 945865-21-4; 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester.
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.