Description

1H-Indazole, 7-[2-(Trimethylsilyl)Ethynyl]- is a high-purity, advanced pharmaceutical intermediate featuring a unique indazole core functionalized with a trimethylsilyl-protected ethynyl group. This compound is of significant value for its role in facilitating complex organic syntheses, particularly in the construction of novel molecular architectures for drug discovery. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and biotechnology sectors who require specialized building blocks for medicinal chemistry and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting kinase inhibition and other therapeutic pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical space.
• Organic Synthesis Reagent: Serves as a versatile synthon in cross-coupling reactions (e.g., Sonogashira, Heck) due to its ethynyl functionality.
• Chemical Probe Development: Employed in the creation of molecular probes for biochemical and cellular assays to study biological mechanisms.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents and pesticides.
• Material Science Precursor: Can be utilized in the synthesis of organic electronic materials and ligands for catalysis.

Basic Information

Product Name	1H-Indazole, 7-[2-(Trimethylsilyl)Ethynyl]-
CAS No.	945761-98-8
Molecular Formula	C₁₄H₁₈N₂Si
Molecular Weight	242.39 g/mol
Synonyms	7-[(Trimethylsilyl)ethynyl]-1H-indazole; 7-(2-Trimethylsilylethynyl)-1H-indazole; 7-(Trimethylsilylethynyl)indazole; 7-Ethynyl-1H-indazole, trimethylsilyl derivative; 1H-Indazole-7-carbonitrile, α-(trimethylsilyl)-; TMS-ethynyl indazole; 7-TMS-ethynylindazole
EINECS	Contact for details

Quality Control

Our 1H-Indazole, 7-[2-(Trimethylsilyl)Ethynyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.