Description

2-Chloro-4-Ethynylpyridine is a versatile pyridine derivative featuring both a halogen and an alkyne functional group, making it a valuable building block in advanced organic synthesis. This compound is particularly significant for its role as a key intermediate in the development of pharmaceuticals, agrochemicals, and functional materials. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its reactive ethynyl group for molecular diversification.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, conductive materials, and metal-organic frameworks (MOFs).
• Chemical Research: Employed in academic and industrial R&D for palladium-catalyzed cross-coupling reactions (e.g., Sonogashira, Suzuki) due to its reactive halogen and alkyne moieties.
• Ligand Synthesis: Acts as a starting material for creating novel ligands used in catalysis and coordination chemistry.
• Bioconjugation: The alkyne group enables its use in click chemistry applications for bioconjugation and labeling of biomolecules.

Basic Information

Item	Detail
Product Name	2-Chloro-4-Ethynylpyridine
CAS No.	945717-09-9
Molecular Formula	C7H4ClN
Molecular Weight	137.57 g/mol
Synonyms	4-Ethynyl-2-chloropyridine; 2-Chloro-4-ethynylpyridine; 2-Chloro-4-pyridylacetylene; 4-(2-Chloropyridin-4-yl)ethyne; 2-Chloro-4-(ethynyl)pyridine; 4-Ethynyl-2-chloro-pyridine; 2-Chloro-4-ethinylpyridine
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Ethynylpyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.