Description

1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylic Acid, 4-Iodo-, 1,1-Dimethylethyl Ester is a high-value, iodinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because it serves as a critical intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile pyrazolopyridine core and reactive iodine handle.
• Agrochemical Synthesis: Intermediate in the development of new pesticides and herbicides with specific biological activity.
• Material Science Precursor: Potential starting material for creating organic electronic materials or metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce diverse aryl or alkynyl groups.
• Chemical Biology Probes: Can be utilized to develop labeled probes or tags for studying biological systems and mechanisms.

Basic Information

Product Name	1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylic Acid, 4-Iodo-, 1,1-Dimethylethyl Ester
CAS No.	945599-35-9
Molecular Formula	C11H12IN3O2
Molecular Weight	345.14 g/mol
Synonyms	tert-Butyl 4-iodo-1H-pyrazolo[3,4-b]pyridine-1-carboxylate; 4-Iodo-1H-pyrazolo[3,4-b]pyridine-1-carboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-iodo-1H-pyrazolo[3,4-b]pyridine; 4-Iodo-1-Boc-1H-pyrazolo[3,4-b]pyridine; 4-Iodo-1H-pyrazolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester; Boc-4-iodo-1H-pyrazolo[3,4-b]pyridine; 1-Boc-4-iodopyrazolo[3,4-b]pyridine
EINECS	Contact for details

Quality Control

Our 1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylic Acid, 4-Iodo-, 1,1-Dimethylethyl Ester is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.