Description

1H-Pyrrolo[2,3-B]Pyridine, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity boronic ester derivative, a crucial building block in modern synthetic chemistry. Its value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex heterocyclic cores found in active pharmaceutical ingredients (APIs), especially in kinase inhibitor and oncology drug discovery.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific pyrrolopyridine motifs.
• Material Science Research: Serves as a precursor for organic electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-rich fused ring system.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a boronic ester coupling partner for the palladium-catalyzed formation of carbon-carbon bonds with aryl or vinyl halides.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and bioconjugation reagents for studying biological systems.
• Ligand Synthesis: Used to prepare sophisticated ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	945256-29-1
Molecular Formula	C13H17BN2O2
Molecular Weight	244.10 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 3-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine-3-boronic acid pinacol ester; 7-Azaindole-3-boronic acid pinacol ester; 3-Borono-1H-pyrrolo[2,3-b]pyridine pinacol ester; 3-(Pinacolboranyl)-1H-pyrrolo[2,3-b]pyridine; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-7-azaindole; 7-Azaindol-3-ylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to moisture. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Assay (NMR)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.