Description

1-(Methylsulfonyl)Pyrazole-4-Boronic Acid Pinacol Ester is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for constructing heterocyclic scaffolds.
• Agrochemical Synthesis: Used in creating advanced crop protection agents and herbicides through palladium-catalyzed coupling reactions.
• Material Science Research: Serves as a precursor in the development of organic electronic materials, such as polymers for OLEDs and organic semiconductors.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugates for studying biological processes.
• Catalyst & Ligand Development: Acts as a starting material for synthesizing novel ligands and organometallic catalysts.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	1-(Methylsulfonyl)Pyrazole-4-Boronic Acid Pinacol Ester
CAS No.	944994-03-0
Molecular Formula	C11H19BN2O4S
Molecular Weight	286.16 g/mol
Synonyms	1-Methanesulfonyl-1H-pyrazole-4-boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(methylsulfonyl)-1H-pyrazole; 1-(Methylsulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1H-Pyrazole-4-boronic acid, 1-(methylsulfonyl)-, pinacol ester; Pyrazole-4-boronic acid pinacol ester, 1-(methylsulfonyl)-; 944994-03-0; 1-Methylsulfonylpyrazole-4-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-(Methylsulfonyl)Pyrazole-4-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our commitment to quality supports compliance in cGMP and ISO environments for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.