Description

4-(3-Fluoro-Phenyl)-3-Oxo-Butyric Acid Methyl Ester is a high-purity fluorinated organic building block, specifically a β-keto ester derivative. This compound is valued for its versatile reactivity, serving as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing fluorinated heterocycles and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated drug candidates, including potential kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and development of novel fluorinated pesticides and herbicides, where the fluorine atom can enhance biological activity and stability.
• Chemical Research: Serves as a versatile building block for Knorr pyrrole synthesis, Paal-Knorr reactions, and other condensation reactions to create complex heterocyclic structures.
• Material Science: Employed in the development of specialty polymers and advanced organic materials that require fluorinated aromatic components.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	4-(3-Fluoro-Phenyl)-3-Oxo-Butyric Acid Methyl Ester
CAS No.	944993-11-7
Molecular Formula	C11H11FO3
Molecular Weight	210.20 g/mol
Synonyms	Methyl 4-(3-fluorophenyl)-3-oxobutanoate; 3-Oxo-4-(3-fluorophenyl)butyric acid methyl ester; 3-(3-Fluorobenzoyl)propionic acid methyl ester; Methyl 3-(3-fluorobenzoyl)propionate; 4-(3-Fluorophenyl)-3-oxobutanoic acid methyl ester; β-Keto ester fluorophenyl derivative; 3-Fluorophenyl acetoacetate methyl ester
EINECS	Contact for details

Quality Control

Our 4-(3-Fluoro-Phenyl)-3-Oxo-Butyric Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.