Description

1-(5-Trifluoromethyl-Pyridin-3-Yl)-Ethanone is a high-purity trifluoromethylpyridine derivative, a key fluorinated building block prized for its ability to impart metabolic stability and lipophilicity to target molecules. This compound is essential for research and development in advanced chemical synthesis, particularly where the introduction of a trifluoromethyl group is required. It is primarily utilized by pharmaceutical, agrochemical, and advanced material scientists for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for synthesizing specialty polymers, liquid crystals, and organic electronic materials requiring fluorinated aromatic systems.
• Chemical Biology & Proteomics: Employed as a building block for designing chemical probes and enzyme inhibitors used in target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical manufacturing.

Basic Information

Product Name	1-(5-Trifluoromethyl-Pyridin-3-Yl)-Ethanone
CAS No.	944904-85-2
Molecular Formula	C8H6F3NO
Molecular Weight	189.14 g/mol
Synonyms	3-Acetyl-5-(trifluoromethyl)pyridine; 1-[5-(Trifluoromethyl)-3-pyridinyl]ethanone; 5-Trifluoromethyl-3-acetylpyridine; Ethanone, 1-[5-(trifluoromethyl)-3-pyridinyl]-; 3-Pyridineacetyl, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)nicotinoyl methyl; 3-Acetyl-5-trifluoromethylpyridine
EINECS	Contact for details

Quality Control

Our 1-(5-Trifluoromethyl-Pyridin-3-Yl)-Ethanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.