Description

1H-Indazole-1-Carboxylic Acid, 3-(Bromomethyl)-5-Fluoro-, 1,1-Dimethylethyl Ester is a high-purity, multi-functional chemical intermediate designed for advanced synthetic applications. Its molecular architecture, featuring both a reactive bromomethyl group and a protected carboxylic acid, makes it a versatile building block for constructing complex heterocyclic compounds. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs) and agrochemicals.

Application

This specialized indazole derivative serves as a critical precursor in several high-value chemical synthesis pathways. Its primary applications include:

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides with enhanced efficacy.
• Chemical Biology Probes: Serves as a scaffold for creating labeled compounds and molecular probes used in biochemical and pharmacological research.
• Material Science: Potential precursor for advanced organic electronic materials and liquid crystals due to its rigid heterocyclic core.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring functionalized indazole cores.

Basic Information

Product Name	1H-Indazole-1-Carboxylic Acid, 3-(Bromomethyl)-5-Fluoro-, 1,1-Dimethylethyl Ester
CAS No.	944904-75-0
Molecular Formula	C14H16BrFN2O2
Molecular Weight	343.19 g/mol
Synonyms	tert-Butyl 3-(bromomethyl)-5-fluoro-1H-indazole-1-carboxylate; 5-Fluoro-3-(bromomethyl)-1H-indazole-1-carboxylic acid tert-butyl ester; 3-(Bromomethyl)-5-fluoro-1-((tert-butoxy)carbonyl)-1H-indazole; 1-(tert-Butoxycarbonyl)-3-(bromomethyl)-5-fluoroindazole; Boc-3-bromomethyl-5-fluoroindazole; 944904-75-0; tert-Butyl 5-fluoro-3-(bromomethyl)indazole-1-carboxylate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support development and cGMP-grade requirements, with specifications tailored to your project phase.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Keep the container tightly sealed in a desiccator for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.