Description

5-Bromospiro[Indoline-3,4'-Piperidine] is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research. It is primarily sought after by R&D scientists and process chemists in pharmaceutical, biotechnology, and fine chemical industries for developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates targeting various receptors.
• Medicinal Chemistry R&D: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its spirocyclic structure.
• CNS Drug Discovery: Serves as a core scaffold for developing compounds aimed at neurological and psychiatric disorders.
• Kinase Inhibitor Development: Utilized in the construction of molecules designed to modulate kinase activity for oncology applications.
• Chemical Biology Probes: Employed in the creation of tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Scale-Up: Supplied for contract research and manufacturing (CRO/CMO) projects requiring this specific brominated spiro-indoline-piperidine motif.

Basic Information

Product Name	5-Bromospiro[Indoline-3,4'-Piperidine]
CAS No.	944899-21-2
Molecular Formula	C13H15BrN2
Molecular Weight	279.18 g/mol
Synonyms	5-Bromo-1,3-dihydrospiro[indole-3,4'-piperidine]; 5-Bromo-1,3-dihydro-2H-spiro[indole-3,4'-piperidine]; 5-Bromospiro[indoline-3,4'-piperidine]; 5-Bromo-2,3-dihydro-1H-spiro[indole-3,4'-piperidine]; 5-Bromospiro[indole-3,4'-piperidine]; 1,3-Dihydro-5-bromospiro[indole-3,4'-piperidine]; Spiro[indoline-3,4'-piperidine], 5-bromo-; 5-Bromo-1H-spiro[indole-3,4'-piperidine]
EINECS	Contact for details

Quality Control

Our 5-Bromospiro[Indoline-3,4'-Piperidine] is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is analyzed using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.