Description

1-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Benzo[D]Imidazol-2(3H)-One is a high-value, advanced pharmaceutical intermediate featuring a benzimidazolone core with a boronic ester pinacol protecting group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl structures. It is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates targeting various therapeutic areas, including oncology and CNS disorders.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aryl/heteroaryl halides and its boronic ester group under palladium catalysis.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with complex aromatic backbones.
• Material Science Precursor: Serves as a monomer or functional unit in the research of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	1-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Benzo[D]Imidazol-2(3H)-One
CAS No.	944805-83-8
Molecular Formula	C₁₆H₂₁BN₂O₃
Molecular Weight	300.16 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1,3-dihydro-2H-benzimidazol-2-one; 1-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-benzimidazol-2-one; 1-Methyl-6-(pinacolboryl)-1H-benzo[d]imidazol-2(3H)-one; 6-(Pinacolboryl)-1-methyl-1H-benzo[d]imidazol-2(3H)-one; 1-Methyl-6-(pinacolatoboryl)-1H-benzo[d]imidazol-2(3H)-one; 1-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2(3H)-one; CAS 944805-83-8
EINECS	Contact for details

Quality Control

Our production of 1-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Benzo[D]Imidazol-2(3H)-One adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting critical parameters such as assay purity and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation of the boronic ester functionality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.